Alternative "Legal" Highs: Kratom, Salvia Divinorum, Methoxetamine
- Jan 12th, 2014
- Alex Koyfman
- categories:
General Info / Intro
Kratom |
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Salvia |
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Methoxetamine |
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Clinical Highlights
Kratom |
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Salvia |
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Methoxetamine |
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Bottom Line
Think about the aforementioned substances in a patient with either an opioid, sympathomimetic, or hallucinogenic toxidrome.

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Images from Journal of Forensic Sciences, January 2013
Further Reading
- Kratom exposures reported to Texas poison centers. J Addict Dis. 2013;32(4):396-400.
- Seizure and coma following Kratom (Mitragynina speciosa Korth) exposure. J Med Toxicol. 2010 Dec;6(4):424-6.
- Opioid receptors and legal highs: Salvia divinorum and Kratom. Clin Toxicol (Phila). 2008 Feb;46(2):146-52.
- Bath salts and other emerging toxins. Pediatr Emerg Care. 2014 Jan;30(1):47-52.
- Salvia divinorum: exposures reported to a statewide poison control system over 10 years. J Emerg Med. 2011 Jun;40(6):643-50.
- Methoxetamine toxicity reported to the National Poisons Information Service: clinical characteristics and patterns of enquiries (including the period of the introduction of the UK’s first Temporary Class Drug Order). Emerg Med J. 2014 Jan;31(1):45-7.
- Ketamine-like effects after recreational use of methoxetamine. Ann Emerg Med. 2012 Jul;60(1):97-9.
Discussion Questions/Future Exploration
- “Legal highs” come and go; which will stay / what are the most dangerous to our pts
- How does the market adapt to state / federal bans
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